Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt

Pseudoepitheliomatous hyperplasia (PEH) is a benign condition marked by reactive epithelial proliferation seen in response to various insults like trauma, infection, persistent inflammation and neoplasia. In this report, we discuss case of 35-year-old man who presented with perineal swelling, later turned into non-healing ulcer, first diagnosed as PEH. Still, after clinical suspicion, deeper biopsy was conducted, confirming the diagnosis squamous cell carcinoma directing treatment appropriately. Non-healing lesions are not uncommon. Most turn out be Squamous Cell Carcinoma. But, if histopathological picture suggests Hyperplasia, it vital consider limitations biopsy, solid clinicopathological correlation required look aggressively for underlying Due nature PEH, most cases treated via excision while grafts or flaps occasionally restore severe tissue defects. It therefore crucial rule distinguish from other malignant conditions, prognosis differ widely. utmost importance sample base lesion, analyze multiple sections, data ensure an accurate diagnosis.